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Literature summary extracted from

  • Treede, I.; Jakobsen, L.; Kirpekar, F.; Vester, B.; Weitnauer, G.; Bechthold, A.; Douthwaite, S.
    The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose (2003), Mol. Microbiol., 49, 309-318.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.208 S-adenosyl-L-methionine + uridine2479 in 23S rRNA Streptomyces viridochromogenes AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89 S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
-
 ?
2.1.1.209 S-adenosyl-L-methionine + guanine2535 in 23S rRNA Streptomyces viridochromogenes AviRa modifies guanine2353 within helix 91 of 23S rRNA S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.208 Streptomyces viridochromogenes Q9F5K6
-
-
2.1.1.209 Streptomyces viridochromogenes Q9F5K5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.208 S-adenosyl-L-methionine + uridine2479 in 23S rRNA AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89 Streptomyces viridochromogenes S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
-
 ?
2.1.1.208 S-adenosyl-L-methionine + uridine2479 in 23S rRNA AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89. The exact position of the modification is conformed by MALDI mass spectrometry, a single methyl group is added. No methylation activity with 16S rRNA Streptomyces viridochromogenes S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
-
 ?
2.1.1.209 S-adenosyl-L-methionine + guanine2535 in 23S rRNA AviRa modifies guanine2353 within helix 91 of 23S rRNA Streptomyces viridochromogenes S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA
-
 ?
2.1.1.209 S-adenosyl-L-methionine + guanine2535 in 23S rRNA AviRa modifies guanine2353 within helix 91 of 23S rRNA. The exact position of the modification is conformed by MALDI mass spectrometry, a single methyl group is added. No methylation activity with 16S rRNA Streptomyces viridochromogenes S-adenosyl-L-homocysteine + N1-methylguanine2535 in 23S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.208 AviRb
-
 Streptomyces viridochromogenes
2.1.1.209 AviRa
-
 Streptomyces viridochromogenes

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.208 37
-
 assay at Streptomyces viridochromogenes
2.1.1.209 37
-
 assay at Streptomyces viridochromogenes

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.208 7.5
-
 assay at Streptomyces viridochromogenes
2.1.1.209 7.5
-
 assay at Streptomyces viridochromogenes